Patients should be monitored and managed during and after Activase® (alteplase) administration

Understand the importance of the first 24 hours of Activase treatment

When Activase is administered, the first 24 hours are critical. 2,9,10 Observe and frequently monitor patients for neurologic changes, as well as any signs and symptoms of intracranial hemorrhage and adverse drug reactions, during patient recovery. Use the Activase Therapy Checklist as a guide in tracking patient’s recovery. 

Activase® (alteplase) monitoring checklist

During therapy with Activase

  • Perform neurologic assessment
  • Check for major and/or minor bleeding
  • Monitor blood pressure
  • Monitor for signs of intracranial hemorrhage (ICH)
  • Monitor for signs of orolingual angioedema
  • Discontinue infusion and obtain an emergency CT scan if the patient develops severe headache, acute hypertension, nausea, or vomiting, or has a worsening neurologic examination

After therapy with Activase

  • Continue to monitor for neurologic deterioration
  • Continue to check for major and/or minor bleeding
  • Continue to monitor and control blood pressure
  • Obtain a follow-up CT scan or MRI at 24 hours before starting anticoagulants or antiplatelet agents
  • Continue to monitor for signs of orolingual angioedema

Note: Each of these guidelines or policy statements represents only one possible approach to the treatment of eligible acute ischemic stroke patients. Each healthcare practitioner and institution will need to exercise professional judgment in creating or adopting treatment protocols or guidelines, as well as in the treatment of each individual patient.

Replace or return Activase products as needed >

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