Appropriate patient selection for Activase® (alteplase) is vital in the treatment of acute ischemic stroke (AIS)

Determine patient eligibility by incorporating the following steps:

Identify potentially eligible patients 5

  • Activase is indicated for the treatment of AIS
  • Prior to initiation of treatment, exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms
  • Initiate treatment as soon as possible, but within 3 hours after symptom onset

Confirm contraindications and consider the warnings 5

Contraindications:
  • Do not administer Activase to treat AIS in the following situations in which the risk of bleeding is greater than the potential benefit:
    • Current intracranial hemorrhage (ICH)
    • Subarachnoid hemorrhage
    • Active internal bleeding
    • Recent (within 3 months) intracranial or intraspinal surgery or serious head trauma
    • Presence of intracranial conditions that may increase the risk of bleeding
    • Bleeding diathesisa
    • Current severe uncontrolled hypertension

a The 2016 AHA/ASA scientific rationale for the inclusion and exclusion criteria for IV alteplase in AIS also advises against treatment with IV alteplase in patients 3:

  • With a platelet count <100,000/mm3, international normalized ratio (INR) >1.7, activated partial thromboplastin time (aPTT) >40 seconds, or prothrombin time (PT) >15 seconds
  • Who have a history of warfarin use and an INR >1.7 
  • Who have received a treatment dose of low-molecular-weight heparin within the previous 24 hours
  • Who are taking direct thrombin inhibitors or direct factor Xa inhibitors, unless the laboratory tests are normal or the patient has not received a treatment dose of these agents for >48 hours
Warnings:
  • Monitor patients and take the necessary measures in the following situations:

Bleeding
Activase can cause significant, sometimes fatal, internal or external bleeding, especially at arterial and venous puncture sites. Avoid intramuscular injections and trauma to the patient. Fatal cases of hemorrhage associated with traumatic intubation in patients administered Activase have been reported. Heparin, aspirin, or Activase may cause bleeding complications; therefore carefully monitor for bleeding. If serious bleeding occurs, terminate the Activase infusion.

Orolingual Angioedema
Monitor patients during and for several hours after infusion for orolingual angioedema. If angioedema develops, discontinue the Activase infusion and promptly institute appropriate therapy.

Cholesterol Embolization
Cholesterol embolism, sometimes fatal, has been reported rarely in patients treated with thrombolytic agents.

Coagulation Tests May be Unreliable during Activase Therapy
Coagulation tests and/or measures of fibrinolytic activity may be unreliable during Activase therapy.

Treat eligible patients with Activase 5

The recommended treatment dose of Activase is 0.9 mg/kg (not to exceed 90 mg total treatment dose) infused intravenously over 60 minutes with 10% of the total treatment dose administered as an initial bolus over 1 minute. 5

For information on reconstitution of 50- and 100-mg vials of Activase, please view the reconstitution videos and see the full Prescribing Information

Explore the Activase Clinical Overview >