ACTIVASE (t-PA) FOR ACUTE MASSIVE PULMONARY EMBOLISM (AMPE)
For additional information regarding Activase (t-PA) and the treatment of acute massive PE, please see the resources listed below:
- "Activase® (t-PA) in Acute Massive Pulmonary Embolism" dosing card
- Connect to guidelines from professional associations
Genentech is neither affiliated with nor endorses the organizations listed above.
Important Safety Information
Activase therapy in patients with pulmonary embolism is contraindicated in the following situations because of an increased risk of bleeding, which could result in significant disability or death:
- Active internal bleeding
- History of cerebrovascular accident
- Recent intracranial or intraspinal surgery or trauma (see WARNINGS in full prescribing information)
- Intracranial neoplasm, arteriovenous malformation, or aneurysm
- Known bleeding diathesis
- Severe uncontrolled hypertension

