Home>Additional Indication ACTIVASE (t-PA) FOR ACUTE MASSIVE PULMONARY EMBOLISM (AMPE) For additional information regarding Activase (t-PA) and the treatment of acute massive PE, please see the resources listed below: "Activase® (t-PA) in Acute Massive Pulmonary Embolism" dosing card – Download – Order printed piece(s) Connect to guidelines from professional associations – American College of Chest Physicians – American College of Emergency Physicians Genentech is neither affiliated with nor endorses the organizations listed above. Important Safety Information Activase therapy in patients with pulmonary embolism is contraindicated in the following situations because of an increased risk of bleeding, which could result in significant disability or death: Active internal bleeding History of cerebrovascular accident Recent intracranial or intraspinal surgery or trauma (see WARNINGS in full prescribing information) Intracranial neoplasm, arteriovenous malformation, or aneurysm Known bleeding diathesis Severe uncontrolled hypertension

Indication: Activase (Alteplase) is indicated in the management of acute massive pulmonary embolism (PE) in adults: (1) for the lysis of acute pulmonary emboli, defined as obstruction of blood flow to a lobe or multiple segments of the lungs; (2) for the lysis of pulmonary emboli accompanied by unstable hemodynamics, e.g., failure to maintain blood pressure without supportive measures. The diagnosis should be confirmed by objective means, such as pulmonary angiography or noninvasive procedures such as lung scanning.

Safety Information: All thrombolytic agents increase the risk of bleeding, including intracranial bleeding. Not all patients will be eligible for Activase therapy, including those patients in the following situations, because of an increased risk of bleeding: active internal bleeding; history of cerebrovascular accident; recent intracranial or intraspinal surgery or trauma (see WARNINGS in full prescribing information); intracranial neoplasm, arteriovenous malformation, or aneurysm; known bleeding diathesis; or severe uncontrolled hypertension.