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Physician and patient experience: a telestroke case study

'The size of the hospital doesn't matter. If you are committed, and you have telestroke technology, a small hospital can be as good as any hospital in the world in the first few hours of a stroke.' — Dr David HessDr David Hess of the Medical College of Georgia is a national leader in the development and use of telemedicine for stroke care and is an experienced consulting stroke neurologist. Dr Hess used telemedicine to treat Mr Thomas D, a resident of rural Georgia, who suffered an acute ischemic stroke and was located more than 100 miles from a stroke center.

The following questions and answers are based on interviews given by Dr Hess to WYYZ-AM, Atlanta, on May 20, 2009, and to Regional Radio, Kansas City, about a week later.


What is telemedicine?

Telemedicine is a way to connect a remote doctor or physician or any kind of specialist with a patient and, in this instance, with a rural emergency room.

It usually involves videoconferencing, where a remote physician can examine the patient. The remote physician can also interact with the local physician on-site and look at the CT scans and images. It's basically a way to bring a doctor electronically to any emergency room or any patient anywhere.

Describe the experience of treating Thomas via telemedicine.

I was at my home at the time, and I got the call. It's probably about 100 miles from where I was at the time. They have a little telemedicine cart in their ER and we have a Web-based system, so I was able to use my laptop computer and log on and work the camera and see Thomas.

I was able to interact with him and evaluate his disability. I found that he had right-sided weakness and couldn't speak. I looked at his CT scan and was able to consult with the emergency room physician there. Together we made the decision that he should be treated with IV t-PA. Then after that we helicoptered him to MCG [Medical College of Georgia], the tertiary care center.

Is the use of telestroke becoming more widespread?

I think it's a growing trend, but we have a long way to go. Recent studies showed that about 64%1 of United States hospitals had not used t-PA in the last 2 years. So we have a long way to go, but this is 1 answer to the issue.

There are 2 reasons we don't treat enough people with t-PA. One is that patients don't get to the hospital in time. And the second reason is that they'll go to a hospital that isn't comfortable using t-PA because they don't have a stroke specialist. Telemedicine helps us with that second reason.

We've got to bring specialists to these hospitals via telemedicine or other means. And then we've got to educate the public about getting patients to the hospital even quicker.

Why is telestroke so important in the treatment of stroke?

The issue is that t-PA has to be given within 3 hours of the onset of symptoms, which doesn't allow much time. It doesn't allow us to drive to an emergency room an hour away if we're a consultant.

Less than 5% of Americans with acute ischemic stroke receive t-PA. Some physicians perceive it as being a little risky, because it can cause bleeding, and acute ischemic stroke can be difficult to diagnose.

Safety Information
All thrombolytic agents increase the risk of bleeding, including intracranial bleeding, and should be used only in appropriate patients. Not all patients with acute ischemic stroke will be eligible for Activase therapy, including patients with evidence of recent or active bleeding; recent (within 3 months) intracranial or intraspinal surgery, serious head trauma, or previous stroke; uncontrolled high blood pressure; or impaired blood clotting.

Please click here for full prescribing information.

There's not an easy measurement of acute ischemic stroke, like there's an EKG for heart attack, so it requires a lot of specialist expertise. Ideally, acute ischemic stroke should be treated by an emergency physician in consultation with a neurologist or stroke specialist. And getting those 2 people together within 3 hours and making that decision can be challenging.


Mr Thomas D is a resident of rural Georgia who experienced a stroke and was located too far from a stroke center to receive specialized care in person.

Thomas was treated by Dr David Hess via telemedicine. The following question and answer is based on an interview given by Thomas to Regional Radio, Kansas City.


Describe the experience of being treated via telemedicine.

Well, most of the discussion I don't remember. I couldn't speak and couldn't really understand what people were saying. My wife was the key. When she realized that I was having a stroke, she immediately dialed 911, and when the ambulance drivers got there they knew about the telemedicine in Royston, which is just a few miles from my house.

So they took me there, and they screened and diagnosed me with AIS. They reviewed my history and gave me t-PA. By the next morning, I felt like I was getting back to normal. Over time, I was able to get back to work.

Case drawn from actual patient. Individual results may vary.

Indication
Activase (Alteplase) is indicated for the management of acute ischemic stroke in adults for improving neurological recovery and reducing the incidence of disability. Treatment should only be initiated within 3 hours after the onset of stroke symptoms, and after exclusion of intracranial hemorrhage by a cranial computerized tomography (CT) scan or other diagnostic imaging method sensitive for the presence of hemorrhage (see CONTRAINDICATIONS).

Safety Information
Activase therapy in patients with AIS is contraindicated in certain situations (eg, suspicion of subarachnoid hemorrhage on pretreatment evaluation, recent (within 3 months) intracranial or intraspinal surgery, history of intracranial hemorrhage, uncontrolled hypertension at time of treatment, active internal bleeding, known bleeding diathesis (eg, current use of oral anticoagulants, administration of heparin within 48 hours of onset of stroke, platelet count <100,000) (see CONTRAINDICATIONS for full list).

The most common complication during Activase therapy is bleeding. Should serious bleeding in a critical location (intracranial, gastrointestinal, retroperitoneal, pericardial) occur, Activase therapy should be discontinued immediately. Death and permanent disability are not uncommonly reported in patients who have experienced stroke (including intracranial bleeding) and other serious bleeding episodes.

The risks of Activase therapy may be increased and should be weighed against the anticipated benefits in certain conditions. [See WARNINGS in full prescribing information].

  • Patients with severe neurological deficit (eg, NIHSS >22) at presentation. There is an increased risk of intracranial hemorrhage in these patients.
  • Patients with major early infarct signs on a computerized cranial tomography (CT) scan (eg, substantial edema, mass effect, or midline shift).

Treatment of patients with minor neurological deficit or with rapidly improving symptoms is not recommended.

Orolingual angioedema has been observed in postmarketing experience in patients treated with Activase for AIS. Patients should be monitored during and for several hours after infusion for signs of orolingual angioedema.

Please click here for full prescribing information.


Reference:
1.
Kleindorfer D, Xu Y, Moomaw CJ, Khatri P, Adeoye O. US geographic distribution of rt-PA utilization by hospital for acute ischemic stroke. Stroke. 2009;40;3580-3584