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Based on the AHA Heart Disease and Stroke Statistics — Update
Facts about acute ischemic stroke

In 2008, the American Heart Association Statistics Subcommittee and Stroke Statistics Subcommittee published "Heart Disease and Stroke Statistics — 2008 Update"1

Obtain the complete update

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Incidence2

  • Annually, about 795,000 people have a new or recurrent stroke
    • – Approximately 610,000 of these strokes are first attacks and about 185,000 are recurrent attacks
  • On average, in the United States, every 40 seconds someone has a stroke
  • Stroke is the third leading cause of death in the United States, ranking only behind heart disease and cancer
  • From 1995 to 2005, the stroke death rate fell 29.7%, and the actual number of stroke deaths declined 13.5%
  • Before age 85, men are more likely than women to have a stroke; after age 85, the trend reverses
  • Each year, about 55,000 more women than men have a stroke
  • 87% of all strokes are ischemic. 10% are intracerebral hemorrhages, and 3% are subarachnoid hemorrhage strokes

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Risk factors2,3

  • In adults over 55 years of age, the lifetime risk for stroke is greater than 1 in 6. Women have a higher risk of stroke than men, which may be owing to women's survival advantage
  • Blacks have a risk of first-ever stroke that is almost twice that of whites. The age-adjusted stroke rates in people 45 to 84 years of age are 6.6 per 1000 population in black men, 3.6 per 1000 in white men, 4.9 per 1000 in black women, and 2.3 per 1000 in white women

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Risk prevention2,3

  • Blood pressure is a powerful risk factor for stroke. People with blood pressure less than 120/80 mm Hg have about half the lifetime risk of stroke as those with hypertension
  • The relative risk of stroke in heavy smokers (those smoking more than 40 cigarettes a day) is twice that of light smokers (those smoking less than 10 cigarettes a day). Stroke risk decreases significantly 2 years after cessation of cigarette smoking and is reduced to the level of nonsmokers by 5 years of abstinence
  • Physical activity reduces stroke risk. The Physicians' Health Study showed a lower stroke risk among men who participated in vigorous exercise than among those who did not
  • Data from the Women's Health Study, which examined stroke risk factors in more than 37,000 women aged 45 or older, suggests that a healthy lifestyle consisting of moderate alcohol consumption, regular exercise, a healthy diet, low body mass index, and abstinence from smoking was associated with a significantly reduced risk of total and ischemic stroke, but not of hemorrhagic stroke
  • The Northern Manhattan Stroke Study — which included whites, blacks, and Hispanics, and women and men in an urban setting — showed a decrease in ischemic stroke risk associated with physical activity levels across all racial/ethnic and age groups and for each gender (OR 0.37)

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Aftermath

Stroke is a leading cause of serious, long-term disability in the United States3

Disabilities in patients 6 months after acute ischemic stroke

  • *
  • Among ischemic stroke survivors at least 65 years of age.

Patients perceive severe stroke outcomes as similar to or worse than death4

Patients perceive severe stroke outcomes as similar to or worse than death(4)

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Cost

The direct and indirect costs of stroke in 2008 in the United States were estimated at $65.5 billion

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Indication
Activase (Alteplase) is indicated for the management of acute ischemic stroke in adults for improving neurological recovery and reducing the incidence of disability. Treatment should only be initiated within 3 hours after the onset of stroke symptoms, and after exclusion of intracranial hemorrhage by a cranial computerized tomography (CT) scan or other diagnostic imaging method sensitive for the presence of hemorrhage (see CONTRAINDICATIONS).

Important Safety Information
Activase therapy in patients with AIS is contraindicated in certain situations (eg, suspicion of subarachnoid hemorrhage on pretreatment evaluation, recent (within 3 months) intracranial or intraspinal surgery, history of intracranial hemorrhage, uncontrolled hypertension at time of treatment, active internal bleeding, known bleeding diathesis (eg, current use of oral anticoagulants, administration of heparin within 48 hours of onset of stroke, platelet count <100,000) (see CONTRAINDICATIONS for full list).

The most common complication during Activase therapy is bleeding. Should serious bleeding in a critical location (intracranial, gastrointestinal, retroperitoneal, pericardial) occur, Activase therapy should be discontinued immediately. Death and permanent disability are not uncommonly reported in patients who have experienced stroke (including intracranial bleeding) and other serious bleeding episodes.

The risks of Activase therapy may be increased and should be weighed against the anticipated benefits in certain conditions. [See WARNINGS in full prescribing information].

  • Patients with severe neurological deficit (eg, NIHSS >22) at presentation. There is an increased risk of intracranial hemorrhage in these patients.
  • Patients with major early infarct signs on a computerized cranial tomography (CT) scan (eg, substantial edema, mass effect, or midline shift).

Treatment of patients with minor neurological deficit or with rapidly improving symptoms is not recommended.

Orolingual angioedema has been observed in postmarketing experience in patients treated with Activase for AIS. Patients should be monitored during and for several hours after infusion for signs of orolingual angioedema.

Please click here for full prescribing information.


References:
1.
Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics — 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008;117:e25-e146.
2.
Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics — 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119:e21-e181.
3.
Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics — 2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115:e69-e171.
4.
Solomon NA, Glick HA, Russo CJ, Lee J, Schulman KA. Patient preferences for stroke outcomes. Stroke. 1994; 25:1721-1725.