- Dosing & Administration Video

Home>About Activase (t-PA) for Stroke>Dosing & Administration Dosing and administration Total dose of Activase (t-PA) should not exceed 90 mg in acute ischemic stroke1 Recommended dose: 0.9 mg/kg infused over 60 minutes (not to exceed 90 mg total dose) – 10% of the total dose is administered as an initial intravenous bolus over 1 minute – Remaining dose to be administered over the next 60 minutes Concomitant administration of heparin and aspirin during the first 24 hours after symptom onset is not recommended Pay special attention to potential bleeding sites (eg, catheter insertion site) Please see full prescribing information. View the Activase (t-PA) Dosing and Administration Video. Print this convenient tool containing Activase (t-PA) dosing and administration information: Frequently Asked Questions Brochure

Indication: Activase is indicated for the management of acute ischemic stroke in adults for improving neurological recovery and reducing the incidence of disability. Treatment should only be initiated within 3 hours after the onset of stroke symptoms, and after exclusion of intracranial hemorrhage by a cranial computerized tomography (CT) scan or other diagnostic imaging method sensitive for the presence of hemorrhage (see CONTRAINDICATIONS in the full prescribing information).

Safety Information: All thrombolytic agents increase the risk of bleeding, including intracranial bleeding, and should be used only in appropriate patients. Not all patients with acute ischemic stroke will be eligible for Activase therapy, including patients with evidence of recent or active bleeding; recent (within 3 months) intracranial or intraspinal surgery, serious head trauma, or previous stroke; uncontrolled high blood pressure; or impaired blood clotting.

Please see full prescribing information.